Mechanochemical Preparation and Biological Activity of Mn (II) Complex from Ciprofloxacin

Shehu Jibril; Kabiru Aliyu Baraya; Auwal Adamu Mahmoud; Jibril Shirama; Samira Muhammad Shehu; Shu’aibu Bala Adamu

doi:doi:10.11648/j.wjac.20220701.14

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Mechanochemical Preparation and Biological Activity of Mn (II) Complex from Ciprofloxacin

Shehu Jibril, Kabiru Aliyu Baraya, Auwal Adamu Mahmoud, Jibril Shirama, Samira Muhammad Shehu, Shu’aibu Bala Adamu

Published in World Journal of Applied Chemistry (Volume 7, Issue 1)

Received: 8 February 2022 Accepted: 7 March 2022 Published: 18 March 2022

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Abstract

The mechanochemically prepared complex [Mn(cip)₂Cl₂] was synthesized using simple neat grinding method and analyzed using spectral studies, elemental analysis and physicochemical properties. The complex shows increase in biological activity compared with both the free ligand of ciprofloxacin and the standard. The IR spectral analysis of the complex, the ligand ciprofloxacin acts as bidentate ligand that indicate a strong band in the spectra at 1707.92 cm^-1 and 1628.81 cm^-1 which was assigned to υ(C=O) cm^-1 υ(COO) cm^-1. It shifted to a lower frequency’s regions of 1707.92 cm^-1 and 1625.40 cm^-1 in the complex indicating the involvement of carbonyl groups of both amide and carboxylic acid in the coordination, the bands at 478.20 cm^-1 and 750.39 cm^-1 which is absent in the free ligand appeared in the complex was assigned to υ(M-O) and υ(M-Cl) band. The value obtained from molar conductivity at 10.7 Ω^-1cm²mol^-1 indicate that the complex is non-electrolyte in DMSO. Both the elemental and physicochemical analysis agreed with the proposed structure of the compound and also suggested one metal to two ligands ratio. Due to environmentally friendly, shortest reactions time, inexpensive, production of higher yields the authors recommend the use of mechanochemical methods over solution-based.

Published in	World Journal of Applied Chemistry (Volume 7, Issue 1)
DOI	10.11648/j.wjac.20220701.14
Page(s)	24-28
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Mechanochemically, Prepared, Complex, Ciprofloxacin

References

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[5]	Mottillo, C., & Frišcic, T. (2017). Advances in solid-state transformations of coordination bonds: from the ball mill to the aging chamber. Molecules, 22 (144), 1-38.
[6]	Yusha’u, M. (2011). Phytochemical screening and antibacterial activity of hibiscus sabdariffa extract against some urinary tract isolates. Biological and Environmental Journal for the Tropics, 8 (2), 83-86.
[7]	Mustapha, A. N., Ndahi, N. P., Paul B. B., & Fugu M. B. (2014). Synthesis, characterization and antimicrobial studies of metal (II) complexes of ciprofloxacin. Journal of Chemical and Pharmaceutical Research, 6 (4), 588-593.
[8]	Ali, I., Wani, W. A., & Saleem, K. (2013). Empirical formulae to structures of metal complexes by molar conductance. Synthesis and Reactivity in Inorganic, Metal-Organic and Nano-Metal Chemistry, 4 (43), 1162-1170.
[9]	Al-Noor, T. H., Al- Jeboori, A. T., & Aziz, M. M. (2013) Synthetic, spectroscopic and antibacterial studies of Fe (II), Co (II), Ni (II), Cu (II) and Zn (II) mixed ligand complexes of nicotinamide and cephalexin antibiotics. Chemistry and Materials Research, 3 (3), 114-125.
[10]	Waziri, I., Mala G. A., Fugu, M. B., Isah, B., & Umaru, U. (2017). Synthesis, spectral characterization and antimicrobial activity of some metal complexes of mixed antibiotics. Chemistry Research Journal. 2 (2) 52.
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[14]	Hashim, A. S., Ali, E. A., & Ahmed, K. (2015). Synthesis and characterization of Al (III) complex with paracetamol. International Journal of Pharmaceutical Quality Assurance, 10 (1), 156-159.
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APA Style

Shehu Jibril, Kabiru Aliyu Baraya, Auwal Adamu Mahmoud, Jibril Shirama, Samira Muhammad Shehu, et al. (2022). Mechanochemical Preparation and Biological Activity of Mn (II) Complex from Ciprofloxacin. World Journal of Applied Chemistry, 7(1), 24-28. https://doi.org/10.11648/j.wjac.20220701.14

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ACS Style

Shehu Jibril; Kabiru Aliyu Baraya; Auwal Adamu Mahmoud; Jibril Shirama; Samira Muhammad Shehu, et al. Mechanochemical Preparation and Biological Activity of Mn (II) Complex from Ciprofloxacin. World J. Appl. Chem. 2022, 7(1), 24-28. doi: 10.11648/j.wjac.20220701.14

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AMA Style

Shehu Jibril, Kabiru Aliyu Baraya, Auwal Adamu Mahmoud, Jibril Shirama, Samira Muhammad Shehu, et al. Mechanochemical Preparation and Biological Activity of Mn (II) Complex from Ciprofloxacin. World J Appl Chem. 2022;7(1):24-28. doi: 10.11648/j.wjac.20220701.14

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@article{10.11648/j.wjac.20220701.14,
  author = {Shehu Jibril and Kabiru Aliyu Baraya and Auwal Adamu Mahmoud and Jibril Shirama and Samira Muhammad Shehu and Shu’aibu Bala Adamu},
  title = {Mechanochemical Preparation and Biological Activity of Mn (II) Complex from Ciprofloxacin},
  journal = {World Journal of Applied Chemistry},
  volume = {7},
  number = {1},
  pages = {24-28},
  doi = {10.11648/j.wjac.20220701.14},
  url = {https://doi.org/10.11648/j.wjac.20220701.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.wjac.20220701.14},
  abstract = {The mechanochemically prepared complex [Mn(cip)2Cl2] was synthesized using simple neat grinding method and analyzed using spectral studies, elemental analysis and physicochemical properties. The complex shows increase in biological activity compared with both the free ligand of ciprofloxacin and the standard. The IR spectral analysis of the complex, the ligand ciprofloxacin acts as bidentate ligand that indicate a strong band in the spectra at 1707.92 cm-1 and 1628.81 cm-1 which was assigned to υ(C=O) cm-1 υ(COO) cm-1. It shifted to a lower frequency’s regions of 1707.92 cm-1 and 1625.40 cm-1 in the complex indicating the involvement of carbonyl groups of both amide and carboxylic acid in the coordination, the bands at 478.20 cm-1 and 750.39 cm-1 which is absent in the free ligand appeared in the complex was assigned to υ(M-O) and υ(M-Cl) band. The value obtained from molar conductivity at 10.7 Ω-1cm2mol-1 indicate that the complex is non-electrolyte in DMSO. Both the elemental and physicochemical analysis agreed with the proposed structure of the compound and also suggested one metal to two ligands ratio. Due to environmentally friendly, shortest reactions time, inexpensive, production of higher yields the authors recommend the use of mechanochemical methods over solution-based.},
 year = {2022}
}

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TY  - JOUR
T1  - Mechanochemical Preparation and Biological Activity of Mn (II) Complex from Ciprofloxacin
AU  - Shehu Jibril
AU  - Kabiru Aliyu Baraya
AU  - Auwal Adamu Mahmoud
AU  - Jibril Shirama
AU  - Samira Muhammad Shehu
AU  - Shu’aibu Bala Adamu
Y1  - 2022/03/18
PY  - 2022
N1  - https://doi.org/10.11648/j.wjac.20220701.14
DO  - 10.11648/j.wjac.20220701.14
T2  - World Journal of Applied Chemistry
JF  - World Journal of Applied Chemistry
JO  - World Journal of Applied Chemistry
SP  - 24
EP  - 28
PB  - Science Publishing Group
SN  - 2637-5982
UR  - https://doi.org/10.11648/j.wjac.20220701.14
AB  - The mechanochemically prepared complex [Mn(cip)2Cl2] was synthesized using simple neat grinding method and analyzed using spectral studies, elemental analysis and physicochemical properties. The complex shows increase in biological activity compared with both the free ligand of ciprofloxacin and the standard. The IR spectral analysis of the complex, the ligand ciprofloxacin acts as bidentate ligand that indicate a strong band in the spectra at 1707.92 cm-1 and 1628.81 cm-1 which was assigned to υ(C=O) cm-1 υ(COO) cm-1. It shifted to a lower frequency’s regions of 1707.92 cm-1 and 1625.40 cm-1 in the complex indicating the involvement of carbonyl groups of both amide and carboxylic acid in the coordination, the bands at 478.20 cm-1 and 750.39 cm-1 which is absent in the free ligand appeared in the complex was assigned to υ(M-O) and υ(M-Cl) band. The value obtained from molar conductivity at 10.7 Ω-1cm2mol-1 indicate that the complex is non-electrolyte in DMSO. Both the elemental and physicochemical analysis agreed with the proposed structure of the compound and also suggested one metal to two ligands ratio. Due to environmentally friendly, shortest reactions time, inexpensive, production of higher yields the authors recommend the use of mechanochemical methods over solution-based.
VL  - 7
IS  - 1
ER  -

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Author Information

Shehu Jibril

Department of Chemistry, Aminu Saleh College of Education, Azare, Nigeria
Kabiru Aliyu Baraya

Department of Chemistry, Aminu Saleh College of Education, Azare, Nigeria
Auwal Adamu Mahmoud

Department of Chemistry, Abubakar Tafawa Balewa University, Bauchi, Nigeria
Jibril Shirama

Department of Chemistry, Aminu Saleh College of Education, Azare, Nigeria
Samira Muhammad Shehu

Department of Chemistry, Aminu Saleh College of Education, Azare, Nigeria
Shu’aibu Bala Adamu

Department of Biology, Aminu Saleh College of Education, Azare, Nigeria

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APA Style

Shehu Jibril, Kabiru Aliyu Baraya, Auwal Adamu Mahmoud, Jibril Shirama, Samira Muhammad Shehu, et al. (2022). Mechanochemical Preparation and Biological Activity of Mn (II) Complex from Ciprofloxacin. World Journal of Applied Chemistry, 7(1), 24-28. https://doi.org/10.11648/j.wjac.20220701.14

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ACS Style

Shehu Jibril; Kabiru Aliyu Baraya; Auwal Adamu Mahmoud; Jibril Shirama; Samira Muhammad Shehu, et al. Mechanochemical Preparation and Biological Activity of Mn (II) Complex from Ciprofloxacin. World J. Appl. Chem. 2022, 7(1), 24-28. doi: 10.11648/j.wjac.20220701.14

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AMA Style

Shehu Jibril, Kabiru Aliyu Baraya, Auwal Adamu Mahmoud, Jibril Shirama, Samira Muhammad Shehu, et al. Mechanochemical Preparation and Biological Activity of Mn (II) Complex from Ciprofloxacin. World J Appl Chem. 2022;7(1):24-28. doi: 10.11648/j.wjac.20220701.14

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@article{10.11648/j.wjac.20220701.14,
  author = {Shehu Jibril and Kabiru Aliyu Baraya and Auwal Adamu Mahmoud and Jibril Shirama and Samira Muhammad Shehu and Shu’aibu Bala Adamu},
  title = {Mechanochemical Preparation and Biological Activity of Mn (II) Complex from Ciprofloxacin},
  journal = {World Journal of Applied Chemistry},
  volume = {7},
  number = {1},
  pages = {24-28},
  doi = {10.11648/j.wjac.20220701.14},
  url = {https://doi.org/10.11648/j.wjac.20220701.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.wjac.20220701.14},
  abstract = {The mechanochemically prepared complex [Mn(cip)2Cl2] was synthesized using simple neat grinding method and analyzed using spectral studies, elemental analysis and physicochemical properties. The complex shows increase in biological activity compared with both the free ligand of ciprofloxacin and the standard. The IR spectral analysis of the complex, the ligand ciprofloxacin acts as bidentate ligand that indicate a strong band in the spectra at 1707.92 cm-1 and 1628.81 cm-1 which was assigned to υ(C=O) cm-1 υ(COO) cm-1. It shifted to a lower frequency’s regions of 1707.92 cm-1 and 1625.40 cm-1 in the complex indicating the involvement of carbonyl groups of both amide and carboxylic acid in the coordination, the bands at 478.20 cm-1 and 750.39 cm-1 which is absent in the free ligand appeared in the complex was assigned to υ(M-O) and υ(M-Cl) band. The value obtained from molar conductivity at 10.7 Ω-1cm2mol-1 indicate that the complex is non-electrolyte in DMSO. Both the elemental and physicochemical analysis agreed with the proposed structure of the compound and also suggested one metal to two ligands ratio. Due to environmentally friendly, shortest reactions time, inexpensive, production of higher yields the authors recommend the use of mechanochemical methods over solution-based.},
 year = {2022}
}

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TY  - JOUR
T1  - Mechanochemical Preparation and Biological Activity of Mn (II) Complex from Ciprofloxacin
AU  - Shehu Jibril
AU  - Kabiru Aliyu Baraya
AU  - Auwal Adamu Mahmoud
AU  - Jibril Shirama
AU  - Samira Muhammad Shehu
AU  - Shu’aibu Bala Adamu
Y1  - 2022/03/18
PY  - 2022
N1  - https://doi.org/10.11648/j.wjac.20220701.14
DO  - 10.11648/j.wjac.20220701.14
T2  - World Journal of Applied Chemistry
JF  - World Journal of Applied Chemistry
JO  - World Journal of Applied Chemistry
SP  - 24
EP  - 28
PB  - Science Publishing Group
SN  - 2637-5982
UR  - https://doi.org/10.11648/j.wjac.20220701.14
AB  - The mechanochemically prepared complex [Mn(cip)2Cl2] was synthesized using simple neat grinding method and analyzed using spectral studies, elemental analysis and physicochemical properties. The complex shows increase in biological activity compared with both the free ligand of ciprofloxacin and the standard. The IR spectral analysis of the complex, the ligand ciprofloxacin acts as bidentate ligand that indicate a strong band in the spectra at 1707.92 cm-1 and 1628.81 cm-1 which was assigned to υ(C=O) cm-1 υ(COO) cm-1. It shifted to a lower frequency’s regions of 1707.92 cm-1 and 1625.40 cm-1 in the complex indicating the involvement of carbonyl groups of both amide and carboxylic acid in the coordination, the bands at 478.20 cm-1 and 750.39 cm-1 which is absent in the free ligand appeared in the complex was assigned to υ(M-O) and υ(M-Cl) band. The value obtained from molar conductivity at 10.7 Ω-1cm2mol-1 indicate that the complex is non-electrolyte in DMSO. Both the elemental and physicochemical analysis agreed with the proposed structure of the compound and also suggested one metal to two ligands ratio. Due to environmentally friendly, shortest reactions time, inexpensive, production of higher yields the authors recommend the use of mechanochemical methods over solution-based.
VL  - 7
IS  - 1
ER  -

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